- V Volt
- VAN Value-Added Network
- VAP Value-Added Process
- VAR Value-Added Reseller
- VARP VINES Address Resolution Protocol
- VAX Virtual Address EXtension
- VBA Visual Basic for Applications
- VBK Visual Basic Killer
- VBNS Very-High Bandwidth Network Service
- VBX Visual Basic EXtension
- VCL Visual Component Library
- VCPI Virtual Control Program Interface
- VCR VideoCassette Recorder
- VCS Version Control System
- VDM Virtual DOS Machine
- VDT Video Display Terminal
- VERONICA Very Easy Rodent-Oriented Netwide Index to Computerized Archives
- VESA Video Equipment Standards Association
- VFRP VINES FRagmentation Protocol
- VGA Video Graphics Array
- vi visual interactive editor
- VICP VINES Internet Control Protocol
- VIM Vendor Independent Messaging
- VINES VIrtual NEtwork Software / VIrtual NEtworking System
- VIP VINES Internet Protocol
- VIPC VINES InterProcess Communications
- VL-BUS VESA Local Bus
- VLIW Very Large Instructive Word
- VLM Virtual Loadable Module
- VLSI Very Large-Scale Integration
- VM Virtual Mode / Virtual Machine
- VMB Voice Mail Box
- VMM Virtual Memory Manager / Virtual Machine Manager
- VMS Virtual Memory System
- VR Virtual Reality
- VRAM Video Random Access Memory
- VRMC Virtual Reality Markup Language
- VRTP VINES RouTing Protocol
- VRU Voice-Response Unit
- VSAM Virtual Storage Access Method
- VSAT Very Small Aperture Terminal
- VSPP VINES Sequenced Packet Protocol
- VT Video Terminal / Virtual Terminal
- VTD Video Terminal Display
- VTE Video Transfer Engine
- VXD Virtual Device Driver (X here stands for Device)